Tilo, the titular “Mistresses of Spices” is a shopkeeper and an immigrant from India who helps customers satisfy their needs and desires with spices. Her life changes when she falls in love with an American man.

A middle-aged Tukaram is passionate about food and archaeology but it’s a misplaced call from Madhura that adds the tadka to his life. While love simmers, Nicole and Sidharth’s story spices up too.